A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters.

ABSTRACT: A strategy for photochemical cleavage of peptide and protein backbones is described, which is based on a selenide-mediated cleavage of a backbone ester moiety. Studies in model systems establish the viability of the chemistry and suggest the method could be a valuable tool for chemical biology studies of proteins.

SUBMITTER: Eastwood AL 

PROVIDER: S-EPMC2953381 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature