Chronic alternate-day fasting results in reduced diastolic compliance and diminished systolic reserve in rats.

ABSTRACT:

Background

Based on animal experiments and limited data from the few human trials, alternate-day fasting (ADF) resulted in weight loss, prolonged life, reduced metabolic risk factors for diabetes and cardiovascular diseases, and reduced prevalence of age-related diseases. The present study is the first comprehensive examination of the long-term effects of ADF on general cardiovascular fitness in rats.

Methods and results

Four-month-old male Sprague-Dawley rats were started on ADF or continued on ad libitum diets and followed for 6 months with serial echocardiography. A comprehensive hemodynamic evaluation including a combined dobutamine-volume stress test was performed at the end of the study, and hearts were harvested for histological assessment. The 6-month-long ADF diet r

SUBMITTER: Ahmet I 

PROVIDER: S-EPMC2953475 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature