Profound depletion of HIV-1 transcription in patients initiating antiretroviral therapy during acute infection.

ABSTRACT:

Background

Although combination antiretroviral therapy (cART) initiated in the acute phase of HIV-1 infection may prevent expansion of the latent reservoir, its benefits remain controversial. In the current study, HIV-1 RNA transcription patterns in peripheral blood mononuclear cells (PBMC) were monitored during acute cART to assess the effect of early treatment on cellular viral reservoirs.

Methodology/principal findings

Acutely HIV-1 infected patients (n = 24) were treated within 3-15 weeks after infection. Patients elected to cease treatment after ≥1 year of therapy. HIV-1 DNA (vDNA), HIV-1 RNA species expressed both in latently and productively infected cells, unspliced (UsRNA), multiply spliced (MsRNA-tatrev; MsRNA-nef), and PBMC-associated extracellular virion RNA (vRe

SUBMITTER: Schmid A 

PROVIDER: S-EPMC2953504 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature