Genome-wide analysis of light- and temperature-entrained circadian transcripts in Caenorhabditis elegans.

ABSTRACT: Most organisms have an endogenous circadian clock that is synchronized to environmental signals such as light and temperature. Although circadian rhythms have been described in the nematode Caenorhabditis elegans at the behavioral level, these rhythms appear to be relatively non-robust. Moreover, in contrast to other animal models, no circadian transcriptional rhythms have been identified. Thus, whether this organism contains a bona fide circadian clock remains an open question. Here we use genome-wide expression profiling experiments to identify light- and temperature-entrained oscillating transcripts in C. elegans. These transcripts exhibit rhythmic expression with temperature-compensated 24-h periods. In addition, their expression is sustained under constant conditions, suggesting that

SUBMITTER: van der Linden AM 

PROVIDER: S-EPMC2953524 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature