Genetics of type 2 diabetes.

ABSTRACT:

Purpose of review

To provide an overview of the genetics of type 2 diabetes in the context of recent progress in the understanding of the genetic architecture of the disease and its applicability to the pathogenesis of the disease as well as efforts to individualize therapy in type 2 diabetes. Efforts are underway to understand how these loci alter measurable physiologic processes in nondiabetic humans. However, it is important to understand the potential pitfalls in such studies and the limitations underlying measurement of insulin secretion and action using qualitative methodologies.

Recent findings

The availability of large population-based cohorts and the ease with which large numbers of common genetic variants can be genotyped has enabled the discovery of multiple loci

SUBMITTER: Smushkin G 

PROVIDER: S-EPMC2953639 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature