Genome-wide patterns of gene expression during aging in the African malaria vector Anopheles gambiae.

ABSTRACT: The primary means of reducing malaria transmission is through reduction in longevity in days of the adult female stage of the Anopheles vector. However, assessing chronological age is limited to crude physiologic methods which categorize the females binomially as either very young (nulliparous) or not very young (parous). Yet the epidemiologically relevant reduction in life span falls within the latter category. Age-grading methods that delineate chronological age, using accurate molecular surrogates based upon gene expression profiles, will allow quantification of the longevity-reducing effects of vector control tools aimed at the adult, female mosquito. In this study, microarray analyses of gene expression profiles in the African malaria vector Anopheles gambiae were conducted during nat

SUBMITTER: Wang MH 

PROVIDER: S-EPMC2954169 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature