A novel secretory poly-cysteine and histidine-tailed metalloprotein (Ts-PCHTP) from Trichinella spiralis (Nematoda).

ABSTRACT:

Background

Trichinella spiralis is an unusual parasitic intracellular nematode causing dedifferentiation of the host myofiber. Trichinella proteomic analyses have identified proteins that act at the interface between the parasite and the host and are probably important for the infection and pathogenesis. Many parasitic proteins, including a number of metalloproteins are unique for the nematodes and trichinellids and therefore present good targets for future therapeutic developments. Furthermore, detailed information on such proteins and their function in the nematode organism would provide better understanding of the parasite-host interactions.

Methodology/principal findings

In this study we report the identification, biochemical characterization and localization of a novel

SUBMITTER: Radoslavov G 

PROVIDER: S-EPMC2954182 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature