Molecular adaptations to aerobic exercise training in skeletal muscle of older women.

ABSTRACT:

Background

We have recently shown that 12 weeks of progressive aerobic exercise training improves whole-muscle size and function in older women. The purpose of this investigation was to evaluate molecular markers that may be associated with muscle hypertrophy after aerobic training in aging skeletal muscle.

Methods

Muscle biopsies were obtained before and after 12 weeks of aerobic exercise training on a cycle ergometer in nine older women (70 ± 2 years) to determine basal levels of messenger RNA and protein content of select myogenic, proteolytic, and mitochondrial factors.

Results

The training program increased (p < .05) aerobic capacity 30 ± 9%, whole-muscle cross-sectional area 11 ± 2%, and whole-muscle force production 29 ± 8%. Basal messenger RNA levels of FOXO3A

SUBMITTER: Konopka AR 

PROVIDER: S-EPMC2954235 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature