Change in circulating adiponectin in advanced old age: determinants and impact on physical function and mortality. The Cardiovascular Health Study All Stars Study.

ABSTRACT:

Background

Cross-sectional studies show that adiponectin is higher in older than in younger adults but long-term change in adiponectin, its determinants, and its relationship to functional decline or survival in the elderly population have not been evaluated.

Methods

We investigated predictors of longitudinal change in adiponectin, and the association of this adipokine or its antecedent change with physical deterioration and all-cause mortality in 988 participants in a population-based study who completed examinations in 1996-1997 and 2005-2006, had serial adiponectin measurements and underwent follow-up through June 2009.

Results

Adiponectin level rose significantly during follow-up, but the increase was smaller in blacks, was associated with declining weight or fast

SUBMITTER: Kizer JR 

PROVIDER: S-EPMC2954239 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature