Research resource: Tissue-specific transcriptomics and cistromics of nuclear receptor signaling: a web research resource.

ABSTRACT: Nuclear receptors (NRs) are ligand-regulated transcription factors that recruit coregulators and other transcription factors to gene promoters to effect regulation of tissue-specific transcriptomes. The prodigious rate at which the NR signaling field has generated high content gene expression and, more recently, genome-wide location analysis datasets has not been matched by a committed effort to archiving this information for routine access by bench and clinical scientists. As a first step towards this goal, we searched the MEDLINE database for studies, which referenced either expression microarray and/or genome-wide location analysis datasets in which a NR or NR ligand was an experimental variable. A total of 1122 studies encompassing 325 unique organs, tissues, primary cells, and cell li

SUBMITTER: Ochsner SA 

PROVIDER: S-EPMC2954640 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature