Hypothalamic responses to fasting indicate metabolic reprogramming away from glycolysis toward lipid oxidation.

ABSTRACT: Nutrient-sensitive hypothalamic neurons regulate energy balance and glucose homeostasis, but the molecular mechanisms mediating hypothalamic responses to nutritional state remain incompletely characterized. To address these mechanisms, the present studies used quantitative PCR to characterize the expression of a panel of genes the hypothalamic expression by nutritional status of which had been suggested by DNA microarray studies. Although these genes regulate a variety of function, the most prominent set regulate intermediary metabolism, and the overall pattern clearly indicated that a 48-h fast produced a metabolic reprogramming away from glucose metabolism and toward the utilization of alternative fuels, particularly lipid metabolism. This general reprogramming of intermediary metabolism

SUBMITTER: Poplawski MM 

PROVIDER: S-EPMC2954726 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature