Temporal and regional regulation of gene expression by calcium-stimulated adenylyl cyclase activity during fear memory.

ABSTRACT:

Background

The Ca2+-stimulated adenylyl cyclases (ACs), AC1 and AC8, are key components of long-term memory processing. AC1 and AC8 double knockout mice (Adcy1(-/-)Adcy8(-/-); DKO) display impaired fear memory processing; the mechanism of this impairment is largely unknown.

Methodology/principal findings

We hypothesize that the Ca2+-stimulated ACs modulate long-lasting transcriptional changes essential for fear memory consolidation and maintenance. Here, we report a genome-wide study of gene expression changes associated with conditioned fear (CF) memory in wild-type and DKO mice to identify AC-dependent gene regulatory changes that occur in the amygdala and hippocampus at baseline and different time points after CF learning. We observed an overall decrease in transcriptiona

SUBMITTER: Wieczorek L 

PROVIDER: S-EPMC2954788 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature