Coxiella burnetii Nine Mile II proteins modulate gene expression of monocytic host cells during infection.

ABSTRACT:

Background

Coxiella burnetii is an intracellular bacterial pathogen that causes acute and chronic disease in humans. Bacterial replication occurs within enlarged parasitophorous vacuoles (PV) of eukaryotic cells, the biogenesis and maintenance of which is dependent on C. burnetii protein synthesis. These observations suggest that C. burnetii actively subverts host cell processes, however little is known about the cellular biology mechanisms manipulated by the pathogen during infection. Here, we examined host cell gene expression changes specifically induced by C. burnetii proteins during infection.

Results

We have identified 36 host cell genes that are specifically regulated when de novo C. burnetii protein synthesis occurs during infection using comparative microarray analy

SUBMITTER: Mahapatra S 

PROVIDER: S-EPMC2954873 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature