EMG1 is essential for mouse pre-implantation embryo development.

ABSTRACT:

Background

Essential for mitotic growth 1 (EMG1) is a highly conserved nucleolar protein identified in yeast to have a critical function in ribosome biogenesis. A mutation in the human EMG1 homolog causes Bowen-Conradi syndrome (BCS), a developmental disorder characterized by severe growth failure and psychomotor retardation leading to death in early childhood. To begin to understand the role of EMG1 in mammalian development, and how its deficiency could lead to Bowen-Conradi syndrome, we have used mouse as a model. The expression of Emg1 during mouse development was examined and mice carrying a null mutation for Emg1 were generated and characterized.

Results

Our studies indicated that Emg1 is broadly expressed during early mouse embryonic development. However, in late embry

SUBMITTER: Wu X 

PROVIDER: S-EPMC2954994 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature