Molecular evolution and the role of oxidative stress in the expansion and functional diversification of cytosolic glutathione transferases.

ABSTRACT:

Background

Cytosolic glutathione transferases (cGST) are a large group of ubiquitous enzymes involved in detoxification and are well known for their undesired side effects during chemotherapy. In this work we have performed thorough phylogenetic analyses to understand the various aspects of the evolution and functional diversification of cGSTs. Furthermore, we assessed plausible correlations between gene duplication and substrate specificity of gene paralogs in humans and selected species, notably in mammalian enzymes and their natural substrates.

Results

We present a molecular phylogeny of cytosolic GSTs that shows that several classes of cGSTs are more ubiquitous and thus have an older ancestry than previously thought. Furthermore, we found that positive selection is impli

SUBMITTER: da Fonseca RR 

PROVIDER: S-EPMC2955027 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature