Position-specific propensities of amino acids in the β-strand.

ABSTRACT:

Background

Despite the importance of β-strands as main building blocks in proteins, the propensity of amino acid in β-strands is not well-understood as it has been more difficult to determine experimentally compared to α-helices. Recent studies have shown that most of the amino acids have significantly high or low propensity towards both ends of β-strands. However, a comprehensive analysis of the sequence dependent amino acid propensities at positions between the ends of the β-strand has not been investigated.

Results

The propensities of the amino acids calculated from a large non-redundant database of proteins are found to be highly position-specific and vary continuously throughout the length of the β-strand. They follow an unexpected characteristic periodic pattern in inn

SUBMITTER: Bhattacharjee N 

PROVIDER: S-EPMC2955036 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature