Dysregulated miR-183 inhibits migration in breast cancer cells.

ABSTRACT:

Background

The involvement of miRNAs in the regulation of fundamental cellular functions has placed them at the fore of ongoing investigations into the processes underlying carcinogenesis. MiRNA expression patterns have been shown to be dysregulated in numerous human malignancies, including breast cancer, suggesting their probable involvement as novel classes of oncogenes or tumour suppressor genes. The identification of differentially expressed miRNAs and elucidation of their functional roles may provide insight into the complex and diverse molecular mechanisms of tumorigenesis. MiR-183 is located on chromosome 7q32 and is part of a miRNA family which are dysregulated in numerous cancers. The aims of this study were to further examine the expression and functional role of miR-183

SUBMITTER: Lowery AJ 

PROVIDER: S-EPMC2955037 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature