Cost-effectiveness of adolescent pertussis vaccination for the Netherlands: using an individual-based dynamic model.

ABSTRACT:

Background

Despite widespread immunization programs, a clear increase in pertussis incidence is apparent in many developed countries during the last decades. Consequently, additional immunization strategies are considered to reduce the burden of disease. The aim of this study is to design an individual-based stochastic dynamic framework to model pertussis transmission in the population in order to predict the epidemiologic and economic consequences of the implementation of universal booster vaccination programs. Using this framework, we estimate the cost-effectiveness of universal adolescent pertussis booster vaccination at the age of 12 years in the Netherlands.

Methods/principal findings

We designed a discrete event simulation (DES) model to predict the epidemiological and

SUBMITTER: de Vries R 

PROVIDER: S-EPMC2955521 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature