Role of interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression.

ABSTRACT:

Background

The use of TNF inhibitors has been a major progress in the treatment of chronic inflammation. However, not all patients respond. In addition, response will be often lost when treatment is stopped. These clinical aspects indicate that other cytokines might be involved and we focus here on the role of IL-17. In addition, the chronic nature of joint inflammation may contribute to reduced response and enhanced chronicity. Therefore we studied the capacity of IL-17 to regulate synoviolin, an E3 ubiquitin ligase implicated in synovial hyperplasia in human rheumatoid arthritis (RA) FLS and in chronic reactivated streptococcal cell wall (SCW)-induced arthritis.

Methodology/principal findings

Chronic reactivated SCW-induced arthritis was examined in IL-17R deficient and wi

SUBMITTER: Toh ML 

PROVIDER: S-EPMC2955522 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature