IQGAP1 is involved in post-ischemic neovascularization by regulating angiogenesis and macrophage infiltration.

ABSTRACT:

Background

Neovascularization is an important repair mechanism in response to ischemic injury and is dependent on inflammation, angiogenesis and reactive oxygen species (ROS). IQGAP1, an actin-binding scaffold protein, is a key regulator for actin cytoskeleton and motility. We previously demonstrated that IQGAP1 mediates vascular endothelial growth factor (VEGF)-induced ROS production and migration of cultured endothelial cells (ECs); however, its role in post-ischemic neovascularization is unknown.

Methodology/principal findings

Ischemia was induced by left femoral artery ligation, which resulted in increased IQGAP1 expression in Mac3(+) macrophages and CD31(+) capillary-like ECs in ischemic legs. Mice lacking IQGAP1 exhibited a significant reduction in the post-ischemic ne

SUBMITTER: Urao N 

PROVIDER: S-EPMC2955540 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature