CoAIMs: a cost-effective panel of ancestry informative markers for determining continental origins.

ABSTRACT:

Background

Genetic ancestry is known to impact outcomes of genotype-phenotype studies that are designed to identify risk for common diseases in human populations. Failure to control for population stratification due to genetic ancestry can significantly confound results of disease association studies. Moreover, ancestry is a critical factor in assessing lifetime risk of disease, and can play an important role in optimizing treatment. As modern medicine moves towards using personal genetic information for clinical applications, it is important to determine genetic ancestry in an accurate, cost-effective and efficient manner. Self-identified race is a common method used to track and control for population stratification; however, social constructs of race are not necessarily informat

SUBMITTER: Londin ER 

PROVIDER: S-EPMC2955551 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature