Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children.

ABSTRACT:

Background

Fat-mass and obesity-associated (FTO) gene is a gene located in chromosome region 16q12.2. Genetic variants in FTO are associated with the obesity phenotype in European and Hispanic populations. However, this association still remains controversial in Asian population. We aimed to test the association of FTO genetic variants with obesity and obesity-related metabolic traits among children living in Beijing, China.

Methods

We genotyped FTO variants rs9939609 in 670 children (332 girls and 338 boys) aged 8-11 years living in Beijing, and analyzed its association with obesity and obesity-related metabolic traits. Overweight and obesity were defined by age- and sex-specific BMI reference for Chinese children. Obesity-related metabolic traits included fasting plasma gl

SUBMITTER: Fang H 

PROVIDER: S-EPMC2955568 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature