Protein connectivity and protein complexity promotes human gene duplicability in a mutually exclusive manner.

ABSTRACT: It has previously been reported that protein complexity (i.e. number of subunits in a protein complex) is negatively correlated to gene duplicability in yeast as well as in humans. However, unlike in yeast, protein connectivity in a protein-protein interaction network has a positive correlation with gene duplicability in human genes. In the present study, we have analyzed 1732 human and 1269 yeast proteins that are present both in a protein-protein interaction network as well as in a protein complex network. In the human case, we observed that both protein connectivity and protein complexity complement each other in a mutually exclusive manner over gene duplicability in a positive direction. Analysis of human haploinsufficient proteins and large protein complexes (complex size >10) shows t

SUBMITTER: Bhattacharya T 

PROVIDER: S-EPMC2955712 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature