Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia.

ABSTRACT: Psychosis has been associated with aberrant brain activity concurrent with both the anticipation and integration of monetary outcomes. The extent to which abnormal reward-related neural signals can be observed in chronic, medicated patients with schizophrenia (SZ), however, is not clear. In an fMRI study involving 17 chronic outpatients with SZ and 17 matched controls, we used a monetary incentive delay (MID) task, in which different-colored shapes predicted gains, losses, or neutral outcomes. Subjects needed to respond to a target within a time window in order to receive the indicated gain or avoid the indicated loss. Group differences in blood-oxygen-level-dependent responses to cues and outcomes were assessed through voxel-wise whole-brain analyses and regions-of-interest analyses in th

SUBMITTER: Waltz JA 

PROVIDER: S-EPMC2955756 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature