Genome-wide association scan of trait depression.

ABSTRACT:

Background

Independent of temporal circumstances, some individuals have greater susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and loneliness. Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders.

Methods

Genome-wide association scans for the depression scale of the Revised NEO Personality Inventory in community-based samples from a genetically homogeneous area of Sardinia, Italy (n = 3972) and from the Baltimore Longitudinal Study of Aging in the United States (n = 839).

Results

Meta-analytic results for genotyped or imputed single nucleotide polymorphisms indicate that the strongest association signals for trait depres

SUBMITTER: Terracciano A 

PROVIDER: S-EPMC2955852 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature