A Six-SNP haplotype of ADAM33 is associated with asthma in a population of Cartagena, Colombia.

ABSTRACT:

Background

A disintegrin and metalloprotein-33 (ADAM33) participates in the bronchial remodeling process in asthma, and genetic analyses pointed it out as a candidate gene in asthma.

Methods

To analyze the association between ADAM33 and asthma and total and mite-specific IgE levels in a population of the Caribbean Coast of Colombia, we genotyped 6 single-nucleotide polymorphisms of ADAM33 in 429 asthmatics, 401 controls and 116 family trios using fluorogenic probes. Total and specific IgE against Blomia tropicalis and Dermatophagoides pteronyssinus were determined by ELISA. Case-control and family-based analyses were performed. Case-control association analyses were corrected by population stratification using a set of 52 ancestry-informative markers.

Results

Eight co

SUBMITTER: Vergara CI 

PROVIDER: S-EPMC2956007 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature