Genetic variants in major histocompatibility complex-linked genes associate with pediatric liver transplant rejection.

ABSTRACT:

Background & aims

Limited access to large samples precludes genome-wide association studies of rare but complex traits. To localize candidate genes with family-based genome-wide association, a novel exploratory analysis was first tested on 1774 major histocompatibility complex single nucleotide polymorphisms (SNPs) in 240 DNA samples from 80 children with primary liver transplantation and their biologic parents.

Methods

Initially, 57 SNPs with large differences (P < .05) in minor allele frequencies were selected when parents of children with early rejection (rejectors) were compared with parents of nonrejectors.

Results

In hypothesis testing of selected SNPs, the gamete competition statistic identified the minor allele G of the SNP rs9296068, near HLA-DOA, as being si

SUBMITTER: Sindhi R 

PROVIDER: S-EPMC2956436 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature