Aortic root remodeling over the adult life course: longitudinal data from the Framingham Heart Study.

ABSTRACT:

Background

Aortic root remodeling in adulthood is known to be associated with cardiovascular outcomes. However, there is a lack of longitudinal data defining the clinical correlates of aortic root remodeling over the adult life course.

Methods and results

We used serial routine echocardiograms in participants of the Framingham Heart Study to track aortic root diameter over 16 years in mid to late adulthood and to determine its short-term (4 years; n=6099 observations in 3506 individuals) and long-term (16 years; n=14,628 observations in 4542 individuals) clinical correlates by multilevel modeling. Age, sex, body size, and blood pressure were principal correlates of aortic remodeling in both short- and long-term analyses (all P < or = 0.01). Aortic root diameter increased wit

SUBMITTER: Lam CS 

PROVIDER: S-EPMC2956587 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature