Genetic variation and neuroimaging measures in Alzheimer disease.

ABSTRACT:

Objective

To investigate whether genome-wide association study (GWAS)-validated and GWAS-promising candidate loci influence magnetic resonance imaging measures and clinical Alzheimer's disease (AD) status.

Design

Multicenter case-control study of genetic and neuroimaging data from the Alzheimer's Disease Neuroimaging Initiative.

Setting

Multicenter GWAS. Patients A total of 168 individuals with probable AD, 357 with mild cognitive impairment, and 215 cognitively normal control individuals recruited from more than 50 Alzheimer's Disease Neuroimaging Initiative centers in the United States and Canada. All study participants had APOE and genome-wide genetic data available.

Main outcome measures

We investigated the influence of GWAS-validated and GWAS-promising nov

SUBMITTER: Biffi A 

PROVIDER: S-EPMC2956757 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature