Distribution and responsiveness of rat anti-Mullerian hormone during ovarian development and VCD-induced ovotoxicity.

ABSTRACT: Anti-Müllerian hormone (AMH) is produced by granulosa cells in primary to small antral follicles of the adult ovary and helps maintain primordial follicles in a dormant state. The industrial chemical, 4-vinylcyclohexene diepoxide (VCD) causes specific ovotoxicity in primordial and small primary follicles of mice and rats. Previous studies suggest that this ovotoxicity involves acceleration of primordial to primary follicle recruitment via interactions with the Kit/Kit ligand signaling pathway. Because of its accepted role in inhibiting primordial follicle recruitment, the present study was designed to investigate a possible interaction between AMH and VCD-induced ovotoxicity. Protein distribution of AMH was compared in neonatal and adult F344 rat ovaries. AMH protein was visualized by immu

SUBMITTER: Mark-Kappeler CJ 

PROVIDER: S-EPMC2956858 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature