Proteomic and functional analysis of the mitotic Drosophila centrosome.

ABSTRACT: Regulation of centrosome structure, duplication and segregation is integrated into cellular pathways that control cell cycle progression and growth. As part of these pathways, numerous proteins with well-established non-centrosomal localization and function associate with the centrosome to fulfill regulatory functions. In turn, classical centrosomal components take up functional and structural roles as part of other cellular organelles and compartments. Thus, although a comprehensive inventory of centrosome components is missing, emerging evidence indicates that its molecular composition reflects the complexity of its functions. We analysed the Drosophila embryonic centrosomal proteome using immunoisolation in combination with mass spectrometry. The 251 identified components were functiona

SUBMITTER: Muller H 

PROVIDER: S-EPMC2957212 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature