Dynamic decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina.

ABSTRACT: The correct organization of cells within an epithelium is essential for proper tissue and organ morphogenesis. The role of Decapentaplegic/Bone morphogenetic protein (Dpp/BMP) signaling in cellular morphogenesis during epithelial development is poorly understood. In this paper, we used the developing Drosophila pupal retina--looking specifically at the reorganization of glial-like support cells that lie between the retinal ommatidia--to better understand the role of Dpp signaling during epithelial patterning. Our results indicate that Dpp pathway activity is tightly regulated across time in the pupal retina and that epithelial cells in this tissue require Dpp signaling to achieve their correct shape and position within the ommatidial hexagon. These results point to the Dpp pathway as a thi

SUBMITTER: Cordero JB 

PROVIDER: S-EPMC2957290 | biostudies-literature | 2007 May

REPOSITORIES: biostudies-literature