Identification of epistatic effects using a protein-protein interaction database.

ABSTRACT: Epistasis (i.e. gene-gene interaction) has long been recognized as an important mechanism underlying the complexity of the genetic architecture of human traits. Definitions of epistasis range from the purely molecular to the traditional statistical measures of interaction. The statistical detection of epistasis usually does not map onto or easily relate to the biological interactions between genetic variations through their combined influence on gene expression or through their interactions at the gene product (i.e. protein) or DNA level. Recently, greater high-dimensional data on protein-protein interaction (PPI) and gene expression profiles have been collected that enumerates sets of biological interactions. To better align statistical and molecular models of epistasis, we present an exa

SUBMITTER: Sun YV 

PROVIDER: S-EPMC2957319 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature