Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study.

ABSTRACT:

Background

Several clinical studies report increased risk of diabetes mellitus with pharmacologic treatment for hypertension (HTN). HTN genes may modify glycemic response to antihypertensive treatment.

Method

The current study examined the association of 24 single nucleotide polymorphisms (SNPs) in 11 HTN candidate genes with fasting glucose measured at 2, 4, and 6 years after treatment initiation. The study sample included participants free of diabetes at baseline in the Genetics of Hypertension Associated Treatment (GenHAT) study (N = 9309). GenHAT participants were randomized to receive treatment with a diuretic (chlorthalidone), calcium channel blocker (amlodipine), or angiotensin-converting enzyme (ACE) inhibitor (lisinopril). Mixed models for repeated measures were emp

SUBMITTER: Irvin MR 

PROVIDER: S-EPMC2957368 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature