Frequent and efficient use of the sister chromatid for DNA double-strand break repair during budding yeast meiosis.

ABSTRACT: Recombination between homologous chromosomes of different parental origin (homologs) is necessary for their accurate segregation during meiosis. It has been suggested that meiotic inter-homolog recombination is promoted by a barrier to inter-sister-chromatid recombination, imposed by meiosis-specific components of the chromosome axis. Consistent with this, measures of Holliday junction-containing recombination intermediates (joint molecules [JMs]) show a strong bias towards inter-homolog and against inter-sister JMs. However, recombination between sister chromatids also has an important role in meiosis. The genomes of diploid organisms in natural populations are highly polymorphic for insertions and deletions, and meiotic double-strand breaks (DSBs) that form within such polymorphic region

SUBMITTER: Goldfarb T 

PROVIDER: S-EPMC2957403 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature