DEGAS: de novo discovery of dysregulated pathways in human diseases.

ABSTRACT:

Background

Molecular studies of the human disease transcriptome typically involve a search for genes whose expression is significantly dysregulated in sick individuals compared to healthy controls. Recent studies have found that only a small number of the genes in human disease-related pathways show consistent dysregulation in sick individuals. However, those studies found that some pathway genes are affected in most sick individuals, but genes can differ among individuals. While a pathway is usually defined as a set of genes known to share a specific function, pathway boundaries are frequently difficult to assign, and methods that rely on such definition cannot discover novel pathways. Protein interaction networks can potentially be used to overcome these problems.

Methodology/

SUBMITTER: Ulitsky I 

PROVIDER: S-EPMC2957424 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature