Bypass mechanisms of the androgen receptor pathway in therapy-resistant prostate cancer cell models.

ABSTRACT:

Background

Prostate cancer is initially dependent on androgens for survival and growth, making hormonal therapy the cornerstone treatment for late-stage tumors. However, despite initial remission, the cancer will inevitably recur. The present study was designed to investigate how androgen-dependent prostate cancer cells eventually survive and resume growth under androgen-deprived and antiandrogen supplemented conditions. As model system, we used the androgen-responsive PC346C cell line and its therapy-resistant sublines: PC346DCC, PC346Flu1 and PC346Flu2.

Methodology/principal findings

Microarray technology was used to analyze differences in gene expression between the androgen-responsive and therapy-resistant PC346 cell lines. Microarray analysis revealed 487 transcripts di

SUBMITTER: Marques RB 

PROVIDER: S-EPMC2957443 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature