The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance.

ABSTRACT:

Importance of the field

Disrupted l-methionine (Met) metabolism can lead to hepatic, neurological and cardiovascular dysfunction in humans. Aberrant methyl group flux likely contributes to the development of these pathologies, but when patients also become hypermethionemic, additional toxicological mechanisms may be relevant.

Areas covered in this review

Following a discussion of the causes of hypermethionemia in humans, evidence for the toxicological roles and clinical significance of the Met transmethylation (TM), transamination (TA) and sulfoxidation (SO) pathways will be presented.

What the reader will gain

Recent data from freshly isolated mouse hepatocytes (FIMHs) confirmed previous in vivo results in rodents that Met TM is a detoxification pathway while Met TA

SUBMITTER: Dever JT 

PROVIDER: S-EPMC2957509 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature