Intrinsically disordered domains deviate significantly from random sequences in mammalian proteins.

ABSTRACT:

Background

In order to characterize mammalian intrinsically disordered domains (IDDs) we examined the patterns in their amino acid abundance as well as overrepresented local sequence motifs. We considered IDDs from mouse proteins associated with innate immune responses as well as a set of generic human genes. These sets were compared with artificially generated random sequences with the same overall amino acid abundance and length distributions. IDDs were then clustered by amino acid abundance, and further analyzed in terms of co-occurrence of clusters with functionally characterized Pfam domains.

Results

Overall, IDDs were very different from randomly generated sequences. The deviation from random distributions was at least as great as that for ordered domains, for which th

SUBMITTER: Teraguchi S 

PROVIDER: S-EPMC2957690 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature