Identification and modeling of a drug target for Clostridium perfringens SM101.

ABSTRACT: In the present study, comparative genome analysis between Clostridium perfringens and the human genome was carried out to identify genes that are essential for the pathogen's survival, and non-homologous to the genes of human host, that can be used as potential drug targets. The study resulted in the identification of 426 such genes. The number of these potential drug targets thus identified is significantly lower than the genome's protein coding capacity (2558 protein coding genes). The 426 genes of C. perfringens were further analyzed for overall similarities with the essential genes of 14 different bacterial species present in Database of Essential Genes (DEG). Our results show that there are only 5 essential genes of C. perfringens that exhibit similarity with 12 species of the 14 diff

SUBMITTER: Chhabra G 

PROVIDER: S-EPMC2957761 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature