Interaction modes at protein hetero-dimer interfaces.

ABSTRACT: Hetero dimer (different monomers) interfaces are involved in catalysis and regulation through the formation of interface active sites. This is critical in cell and molecular biology events. The physical and chemical factors determining the formation of the interface active sites is often large in numbers. The combined role of interacting features is frequently combinatorial and additive in nature. Therefore, it is important to determine the physical and chemical features of such interactions. A number of such features have been documented in literature since 1975. However, the use of such interaction features in the prediction of interaction partners and sites given their sequences is still a challenge. In a non-redundant dataset of 156 hetero-dimer structures determined by X-ray crystallo

SUBMITTER: Vaishnavi A 

PROVIDER: S-EPMC2957768 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature