Disease and phenotype gene set analysis of disease-based gene expression in mouse and human.

ABSTRACT: The genetic contributions to common disease and complex disease phenotypes are pleiotropic, multifactorial, and combinatorial. Gene set analysis is a computational approach used in the analysis of microarray data to rapidly query gene combinations and multifactorial processes. Here we use novel gene sets based on population-based human genetic associations in common human disease or experimental genetic mouse models to analyze disease-related microarray studies. We developed a web-based analysis tool that uses these novel disease- and phenotype-related gene sets to analyze microarray-based gene expression data. These gene sets show disease and phenotype specificity in a species-specific and cross-species fashion. In this way, we integrate population-based common human disease genetics, mou

SUBMITTER: De S 

PROVIDER: S-EPMC2957794 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature