Common variants in HSPB7 and FRMD4B associated with advanced heart failure.

ABSTRACT:

Background

Heart failure results from abnormalities in multiple biological processes that contribute to cardiac dysfunction. We tested the hypothesis that inherited variation in genes of known importance to cardiovascular biology would thus contribute to heart failure risk.

Methods and results

We used the ITMAT/Broad/CARe cardiovascular single-nucleotide polymorphism array to screen referral populations of patients with advanced heart failure for variants in approximately 2000 genes of predicted importance to cardiovascular biology. Our design was a 2-stage case-control study. In stage 1, genotypes in Caucasian patients with heart failure (n=1590; ejection fraction, 32+/-16%) were compared with those in unaffected controls (n=577; ejection fraction, 67+/-8%) who were recruit

SUBMITTER: Cappola TP 

PROVIDER: S-EPMC2957840 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature