Multicentric validation of proteomic biomarkers in urine specific for diabetic nephropathy.

ABSTRACT:

Background

Urine proteome analysis is rapidly emerging as a tool for diagnosis and prognosis in disease states. For diagnosis of diabetic nephropathy (DN), urinary proteome analysis was successfully applied in a pilot study. The validity of the previously established proteomic biomarkers with respect to the diagnostic and prognostic potential was assessed on a separate set of patients recruited at three different European centers. In this case-control study of 148 Caucasian patients with diabetes mellitus type 2 and duration ≥5 years, cases of DN were defined as albuminuria >300 mg/d and diabetic retinopathy (n = 66). Controls were matched for gender and diabetes duration (n = 82).

Methodology/principal findings

Proteome analysis was performed blinded using high-resolution c

SUBMITTER: Alkhalaf A 

PROVIDER: S-EPMC2958112 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature