ADAM17 deletion in thymic epithelial cells alters aire expression without affecting T cell developmental progression.

ABSTRACT:

Background

Cellular interactions between thymocytes and thymic stromal cells are critical for normal T cell development. Thymic epithelial cells (TECs) are important stromal niche cells that provide essential growth factors, cytokines, and present self-antigens to developing thymocytes. The identification of genes that mediate cellular crosstalk in the thymus is ongoing. One candidate gene, Adam17, encodes a metalloprotease that functions by cleaving the ectodomain of several transmembrane proteins and regulates various developmental processes. In conventional Adam17 knockout mice, a non-cell autonomous role for ADAM17 in adult T cell development was reported, which strongly suggested that expression of ADAM17 in TECs was required for normal T cell development. However, knockdown o

SUBMITTER: Gravano DM 

PROVIDER: S-EPMC2958126 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature