Childhood obesity, other cardiovascular risk factors, and premature death.

ABSTRACT:

Background

The effect of childhood risk factors for cardiovascular disease on adult mortality is poorly understood.

Methods

In a cohort of 4857 American Indian children without diabetes (mean age, 11.3 years; 12,659 examinations) who were born between 1945 and 1984, we assessed whether body-mass index (BMI), glucose tolerance, and blood pressure and cholesterol levels predicted premature death. Risk factors were standardized according to sex and age. Proportional-hazards models were used to assess whether each risk factor was associated with time to death occurring before 55 years of age. Models were adjusted for baseline age, sex, birth cohort, and Pima or Tohono O'odham Indian heritage.

Results

There were 166 deaths from endogenous causes (3.4% of the cohort) during

SUBMITTER: Franks PW 

PROVIDER: S-EPMC2958822 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature