Functional protein network activation mapping reveals new potential molecular drug targets for poor prognosis pediatric BCP-ALL.

ABSTRACT:

Background

In spite of leukemia therapy improvements obtained over the last decades, therapy is not yet effective in all cases. Current approaches in Acute Lymphoblastic Leukemia (ALL) research focus on identifying new molecular targets to improve outcome for patients with a dismal prognosis. In this light phosphoproteomics seems to hold great promise for the identification of proteins suitable for targeted therapy.

Methodology/principal findings

We employed Reverse Phase Protein Microarrays to identify aberrantly activated proteins in 118 pediatric B-cell precursor (BCP)-ALL patients. Signal transduction pathways were assayed for activation/expression status of 92 key signalling proteins. We observed an increased activation/expression of several pathways involved in cell pr

SUBMITTER: Accordi B 

PROVIDER: S-EPMC2958847 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature