Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex.

ABSTRACT: Tissue homeostasis depends on the ability of stem cells to properly regulate self-renewal versus differentiation. Drosophila neural stem cells (neuroblasts) are a model system to study self-renewal and differentiation. Recent work has identified two types of larval neuroblasts that have different self-renewal/differentiation properties. Type I neuroblasts bud off a series of small basal daughter cells (ganglion mother cells) that each generate two neurons. Type II neuroblasts bud off small basal daughter cells called intermediate progenitors (INPs), with each INP generating 6 to 12 neurons. Type I neuroblasts and INPs have nuclear Asense and cytoplasmic Prospero, whereas type II neuroblasts lack both these transcription factors. Here we test whether Prospero distinguishes type I/II neurobl

SUBMITTER: Bayraktar OA 

PROVIDER: S-EPMC2958855 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature