The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI.

ABSTRACT:

Background

Variation in the effects of genetic variants on physiological traits over time or with age may alter the trajectories of these traits. However, few studies have investigated this possibility for variants associated with type 2 diabetes or obesity, and these show little consensus. We aimed to characterise the possible longitudinal associations of common diabetes-susceptibility variants in the KCNJ11, PPARG, TCF7L2, IGF2BP2, CDKAL1, SLC30A8 and HHEX gene loci, with fasting glucose level; and of an obesity-associated variant in the FTO gene, with body mass index (BMI).

Methods

The study analysed data from the Busselton Health Study (n = 4,554). Cross-sectional association analyses included family data and used the total association test. Longitudinal association anal

SUBMITTER: Webster RJ 

PROVIDER: S-EPMC2958899 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature