Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent.

ABSTRACT:

Background

The INSIG2 gene has been implicated in cholesterol metabolism and a single nucleotide polymorphism (SNP) near INSIG2 has been shown to be associated with obesity. We sought to determine the relationship of the INSIG2 SNP to cardiovascular disease (CVD) related phenotypes.

Methods and results

Nine hundred forty six patients undergoing percutaneous coronary intervention (PCI) in wave 5 of the multicenter NHLBI Dynamic Registry were genotyped using RT-PCR/TaqMan/allelic discrimination for the rs7566605 SNP near the INSIG2 gene. Clinical variables analyzed include demographics, medical history, and procedural details. The prevalence of peripheral vascular disease (PVD) was significantly higher in older men (≥65 years) who were either homozygous or carriers of the obes

SUBMITTER: Skelding KA 

PROVIDER: S-EPMC2958931 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature